IL-18 production upon s100 stimulation is reduced in active sJIA patients compared to sJIA patients in remission and healthy controls
نویسندگان
چکیده
Introduction Systemic onset Juvenile Idiopathic Artritis (sJIA) is considered to be an autoinflammatory disease. The S100-proteins S100A8, S100A9 and S100A12 in serum and interleukin (IL)-18 in plasma are extremely elevated in sJIA patients and have been proposed to be useful biomarkers for diagnosis, disease activity and response to therapy. Moreover, sJIA patients seem to have a defective IL-18 NK cell axis as NK cell lytic function is impaired in spite of high IL-18 levels. However, it is still unknown how the inflammatory S100 proteins and IL-18 relate to each other, and to the defective NK cell lytic function.
منابع مشابه
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